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  Slides:
The Past, Present, and Future
Clostridium difficile-Associated Disease
Rates of CDAD Tripled in US Hospitals
Annual VHA Discharges with C. difficile
Epidemics
VHA CDAD Rates by Age
CDAD Rates and Mortality
Rates* of C. difficile Enterocolitis as Underlying Cause of Death on US Death Certificates
Pathogenicity of C. difficile
Toxigenic and Non-Toxigenic C. difficile Strains
Typing Systems/Nomenclature for
Possible Virulence Factors
States with the Epidemic Strain of C. difficile
Outbreak Strains Are NOT New: Comparison of
Host Protection Against CDAD
Role of Antibiotics in CDAD
Time-Course of Antimicrobial Effect
Hypothesis for C. difficile Hospital Infection
Reduced Risk of CDAD in Patients
Asymptomatic